**Requirements:** 1. Maintain the original format and structure. 2. The translation should be accurate, fluent, and natural. 3. Maintain professionalism and consistency. 4. Only return the translation result; do not add any explanations. **Original Text:** In 2014, Professor Brian Kennedy, a scientist from Singapore, published a groundbreaking study in the journal *Nature*: Supplementing with AKG (Alpha-Ketoglutaric Acid) could extend the lifespan of the roundworm *C. elegans* by approximately 50%. Subsequent animal experiments further confirmed that AKG increased the healthy lifespan of elderly female mice by 46% and that of male mice by 41%. However, what truly shocked the scientific community was a human study conducted by the National University of Singapore. The study involved 42 volunteers over a period of 7 months, during which they were given a specific dose of Ca-AKG (a highly absorbable form of AKG) daily. The results were astonishing: the average cellular age of the participants decreased by nearly 8 years! More tangible changes included improved sleep quality, increased energy levels, and better skin condition. In less than a year, these volunteers experienced physiological changes that seemed to reverse the effects of aging. **Exploring How AKG Rejuvenates the Body:** 1. **Activating the Cell’s Energy Factory**: AKG directly enters the tricarboxylic acid cycle, promoting the production of ATP (the cell’s energy source), thereby energizing the cells. It also activates the AMPK signaling pathway, which acts as a “power-saving and repair switch” for the cell, activating protective mechanisms when energy is low. 2. **Initiating Cellular Self-Cleaning Processes**: Autophagy is the cell’s mechanism for self-renewal. AKG strongly activates this process, clearing out damaged proteins and old organelles, making space for new cells to form. This is essential for maintaining the youthfulness of tissues. 3. **Building an Anti-Aging Network**: AKG is converted into a precursor of NAD+ in the body, which is a vital fuel for activating longevity-promoting proteins called sirtuins. These proteins are responsible for DNA repair, metabolic regulation, and anti-inflammatory responses, among other anti-aging mechanisms. 4. **Creating an Antioxidant Shield**: As a powerful antioxidant, AKG neutralizes free radicals that cause cellular aging. It also enhances the levels of endogenous antioxidants such as glutathione and superoxide dismutase, providing a dual defense system for the cells. 5. **Genetic Repair**: As we age, DNA damage accumulates. AKG protects genetic integrity by increasing NAD+ levels and activating gene repair enzymes (such as PARP enzymes), which is key to delaying aging at its source. **It’s Important to Note:** AKG is not a “miracle pill.” Addressing the complex process of aging requires a comprehensive approach. While AKG-based interventions can provide cellular support, a healthy diet, moderate exercise, and sufficient sleep remain the foundations of good health. As the study reminds us, aging is a long-term process, and prevention is crucial before the onset of rapid aging.