**Applications:** **Medical Field:** α-Ketoglutaric acid is an important pharmaceutical intermediate that can be used in the synthesis of various drugs. For example, it can be involved in the production of medications for treating liver diseases, heart diseases, and other conditions, helping to improve the body's metabolic functions. Additionally, it possesses antioxidant properties, capable of removing free radicals in the body, which may have a therapeutic effect on certain diseases associated with oxidative stress. **Food Field:** As a food additive, it can be used as an acidulant, flavoring agent, and nutritional fortifier. It adds a unique sour taste to foods and enhances their flavor and texture. Since it is part of the human metabolic process, its appropriate addition to foods can also provide nutritional benefits, contributing to the maintenance of normal physiological functions. **Chemical Industry:** In chemical production, it serves as a raw material for organic synthesis, used in the preparation of various organic compounds. For instance, it can react with amine compounds to form corresponding amides, which are widely used in industries such as coatings, plastics, and rubber. Moreover, α-ketoglutaric acid can be used in the production of biodegradable polymers, which are environmentally friendly. **Biological Field:** Within living organisms, α-ketoglutaric acid is a key intermediate in the tricarboxylic acid cycle, participating in cellular energy metabolism and material metabolism. In biotechnology and fermentation industries, it is commonly used as a nutrient for microbial fermentation, promoting the growth of microorganisms and the synthesis of metabolic products. It can also act as a biomarker for monitoring metabolic states and the progression of diseases within the body.